Sex Steroids and Bone
نویسندگان
چکیده
منابع مشابه
Sex steroids and bone.
The adult skeleton is periodically remodeled by temporary anatomic structures that comprise juxtaposed osteoclast and osteoblast teams and replace old bone with new. Estrogens and androgens slow the rate of bone remodeling and protect against bone loss. Conversely, loss of estrogen leads to increased rate of remodeling and tilts the balance between bone resorption and formation in favor of the ...
متن کاملSex Steroids, Not FSH, Influence Bone Mass
Hypogonadism, whether caused by the failure of gonadal development or function, frequently results in bone loss. In a research article in the April 21, 2006 issue of Cell, Sun et al. investigated the role of follicle-stimulating hormone (FSH) in the bone loss that is characteristic of hypogonadal mice. They report that female mice lacking either FSHβ or its receptor (FSHR) are resistant to bone...
متن کاملSkeletal muscle and bone: effect of sex steroids and aging.
Both estrogen and testosterone are present in males and females. Both hormones contribute to the well being of skeletal muscle and bone in men and women, and there is evidence that the loss of sex hormones is associated with the age-related decline in bone and skeletal muscle mass. Hormonal supplementation of older adults to restore estrogen and testosterone levels to those of young men and wom...
متن کاملResponse: Both FSH and Sex Steroids Influence Bone Mass
In our study (Sun et al., 2006), we conclude that FSH has a direct role in causing bone loss in hypogonadal mice. Our study does not, however, imply that estrogen and testosterone are not critical regulators of bone mass. To the contrary, we assert that sex steroids regulate bone formation and bone resorption, whereas FSH directly stimulates bone resorption. Problems in interpretation can arise...
متن کاملSex Steroids and Bone Health Status in Men
Male osteoporosis is a health problem which deserves more attention as nearly 30% of osteoporotic fractures happen in men aged 50 years and above. Although men do not experience an accelerated bone loss phase and testosterone deficiency is not a universal characteristic for aged men, osteoporosis due to age-related testosterone deficiency does have a negative impact on bone health status of men...
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ژورنال
عنوان ژورنال: Recent Progress in Hormone Research
سال: 2002
ISSN: 0079-9963
DOI: 10.1210/rp.57.1.385